AKT3 (119-136) Rabbit Polyclonal Antibody

CAT#: AP23601PU-N

AKT3 (119-136) rabbit polyclonal antibody

Product Images

Western blot analysis for AKT3 using antibody at 2 ug/ml dilution against 15 ug/lane of HeLa cell lysate.

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  Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated, Synthetic peptide
• Specificity: A synthetic peptide corresponding to amino acid residues 119-136 of human Akt3. This sequence is identical in human, mouse and rat.
• Formulation: PBS, 0.02% sodium azide, 0.1 mg/ml BSA.
  State: Liquid purfied Ig fraction
• Concentration: lot specific
• Purification: Protein G Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (AKT3), transcript variant 1
• Database Link:
  Entrez Gene 23797 MouseEntrez Gene 29414 RatEntrez Gene 10000 Human
  UniProt ID Q9Y243
• Background: AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. AKT3 has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1).
• Synonyms: RAC-PK-gamma, Protein kinase B gamma, PKBG, STK-2

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase
• Protein Pathways: Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Melanoma, mTOR signaling pathway, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Tight junction, Toll-like receptor signaling pathway, VEGF signaling pathway