CXCR2 Rabbit Polyclonal Antibody

CAT#: AP23279PU-N

CXCR2 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of human carcinoma of colon lysis using CXCR2 antibody

• 

  Immunohistochemical analysis of paraffin embedded Human lung cancer sections using CXCR2 antibody

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect CXCR2 in cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect CXCR2 in formalin fixed and paraffin embedded tissues. Boiling the sections is required.
  Immunoprecipitation.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide mapping at the middle region of human CXCR2
• Specificity: This antibody detects CD182 / IL8RB (middle). No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens C-X-C motif chemokine receptor 2 (CXCR2), transcript variant 1
• Database Link:
  Entrez Gene 3579 Human
  UniProt ID P25025
• Background: CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
• Synonyms: CXCR2, CXCR-2, GRO/MGSA receptor, IL-8 receptor type 2, CDw128b, IL8 receptor beta

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection