CMA1 (96-110) Goat Polyclonal Antibody

CAT#: AP23108PU-N

CMA1 (96-110) goat polyclonal antibody, Aff - Purified

Product Images

Testis, mast cells, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Tonsil, mast cells, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1.5 - 3.75 µg/ml.
• Reactivities: Human, Monkey
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human CMA1 / Mast Cell Chymase (NP_001827.1)
• Specificity: This antibody detects Mast Cell Chymase (Internal).
• Formulation: Tris saline, pH 7.3 containing 0.02% sodium azide as preservative and 0.5% BSA as stabilizer
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: chymase 1
• Database Link:
  Entrez Gene 1215 Human
  UniProt ID P23946
• Background: CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II.
• Synonyms: Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM
• Note: Caution: The human mast cell protease I is not the same as the mouse mast cell protease I!

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Renin-angiotensin system