BACE2 Rabbit Polyclonal Antibody

CAT#: AP22930PU-N

Reviews ()
Write a review

Rabbit Polyclonal Anti-BACE2 Antibody, Purified


 Product Datasheet for 'AP22930PU-N'

USD 425.00


Availability*
2 Weeks

Size
    • 50 ug


Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution IHC, WB
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen BACE2 antibody was raised against synthetic peptide corresponding to amino acids near the carboxy terminus of human BACE2
Formulation PBS containing 0.02% sodium azide.
Concentration 1,0 mg/ml
Purification Immunoaffinity Chromatography
Predicted Protein Size 49.8 kDa
Gene Name beta-site APP-cleaving enzyme 2
Background Accumulation of the amyloid-beta (alpha-beta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alpha-beta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alpha-beta (8). BACE2 locates on chromosome 21q22.3, the so-called ¡®Down critical region¡¯, suggesting that BACE2 and aβ may also contribute to the pathogenesis of Down syndrome (6,7)
Synonyms AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
Reference Data
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Alzheimer's disease
Other products for "BACE2"
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
40% off proteins and antibodies
68 Mouse Clones