BACE2 (44-59) Rabbit Polyclonal Antibody

CAT#: AP22917PU-N

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BACE2 (44-59) rabbit polyclonal antibody, Purified

Product Datasheet for 'AP22917PU-N'

USD 525.00

2 Weeks

    • 50 ug

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Product Data
Applications ELISA, IHC, WB
Recommended Dilution ELISA.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 0.5 - 1 µg/ml.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen BACE2 antibody was raised against synthetic peptide (aptpgpgtpaerhadg) corresponding to amino acids 44 to 59 of human BACE2
Specificity This antibody reacts to Beta-site APP-cleaving Enzyme 2 (BACE2).
Formulation PBS containing 0.02% sodium azide as preservative
State: Purified
State: Liquid purified Ig fraction
Concentration 1 mg/ml
Purification Immunoaffinity Chromatography
Gene Name Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a
Background Accumulation of the amyloid-beta (alpha-beta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alpha-beta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within αβ (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alpha beta may also contribute to the pathogenesis of Down syndrome (6,7).
Synonyms Beta-secretase 2, AEPLC, ALP56, ASP21, Memapsin-1, Aspartic-like protease 56 kDa, Down region aspartic protease, ASP1
Reference Data
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Alzheimer's disease
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