BACE2 Rabbit Polyclonal Antibody

CAT#: AP22917PU-N

Rabbit Polyclonal Anti-BACE2 Antibody, Purified


 Product Datasheet for 'AP22917PU-N'

Need it in bulk or conjugated?
Get a free quote

USD 425.00


Availability*
2 Weeks

Size
    • 50 ug

Product images

Specifications

Product Data
Applications WB, IHC
Recommend Dilution IHC, ELISA, WB
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen BACE2 antibody was raised against synthetic peptide (aptpgpgtpaerhadg) corresponding to amino acids 44 to 59 of human BACE2
Isotype IgG
Formulation PBS containing 0.02% sodium azide as preservative
Concentration 0,5 mg/ml
Purification Immunoaffinity Chromatography
Predicted Protein Size 49.8KDa
Gene Name beta-site APP-cleaving enzyme 2
Background Accumulation of the amyloid-beta (alpha-beta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alpha-beta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within aß (8). BACE2 locates on chromosome 21q22.3, the so-called ¡®Down critical region¡¯, suggesting that BACE2 and alpha beta may also contribute to the pathogenesis of Down syndrome (6,7).
Synonyms AEPLC|ALP56|ASP1|ASP21|BAE2|CDA13|CEAP1|DRAP
Reference Data
Protein Families Transmembrane, Protease, Druggable Genome
Protein Pathways Alzheimer's disease
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.