BACE2 (44-59) Rabbit Polyclonal Antibody
BACE2 (44-59) rabbit polyclonal antibody, Purified
|Applications||ELISA, IHC, WB|
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 0.5 - 1 µg/ml.
|Reactivity||Human, Mouse, Rat|
|Immunogen||BACE2 antibody was raised against synthetic peptide (aptpgpgtpaerhadg) corresponding to amino acids 44 to 59 of human BACE2|
|Specificity||This antibody reacts to Beta-site APP-cleaving Enzyme 2 (BACE2).|
|Formulation||PBS containing 0.02% sodium azide as preservative
State: Liquid purified Ig fraction
|Gene Name||Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a|
|Background||Accumulation of the amyloid-beta (alpha-beta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alpha-beta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within αβ (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alpha beta may also contribute to the pathogenesis of Down syndrome (6,7).|
|Synonyms||Beta-secretase 2, AEPLC, ALP56, ASP21, Memapsin-1, Aspartic-like protease 56 kDa, Down region aspartic protease, ASP1|
|Protein Families||Druggable Genome, Protease, Transmembrane|
|Protein Pathways||Alzheimer's disease|