EGFR Sheep Polyclonal Antibody
EGFR sheep polyclonal antibody, Purified
|Applications||IF, IHC, IP, WB|
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Immunoprecipitation: 10 - 12 µg/ml.
|Reactivity||Chicken, Human, Mouse, Rat|
|Immunogen||Synthetic 20 amino acid peptide of human EGFr representing a portion of the internal domain proximal to a phosphorylation region|
|Specificity||This antibody reacts to Epidermal Growth Factor Receptor (EGFR).
This EGFR antibody recognizes a region of the internal domain. Antibody binding blocks phosphorylation and does not interfere with EGF binding.
|Formulation||PBS, pH 7.4
State: Liquid purified Ig fraction
|Purification||Protein G Chromatography|
|Gene Name||Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1|
|Background||Epidermal growth factor receptor (EGFR) is a tyrosine protein kinase comprised of two different components of different molecular weights. Both components contain phosphotyrosine and phosphothreonine but only the higher molecular weight component contains phosphoserine. EGFR signaling involves small GTPases of the Rho family and EGFR trafficking involves small GTPases of the Rab family. EGFR expression is widespread in both normal and cancerous tissues.|
|Synonyms||Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1|
|Protein Families||Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane|
|Protein Pathways||Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.