EGFR Sheep Polyclonal Antibody

CAT#: AP22825PU-N

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EGFR sheep polyclonal antibody, Purified

Product Datasheet for 'AP22825PU-N'

USD 440.00

2 Weeks

    • 50 ug

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Product Data
Applications IF, IHC, IP, WB
Recommend Dilution Immunocytochemistry.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Immunoprecipitation: 10 - 12 µg/ml.
Western Blot.
Reactivity Chicken, Human, Mouse, Rat
Host Sheep
Clonality Polyclonal
Immunogen Synthetic 20 amino acid peptide of human EGFr representing a portion of the internal domain proximal to a phosphorylation region
Specificity This antibody reacts to Epidermal Growth Factor Receptor (EGFR). 
This EGFR antibody recognizes a region of the internal domain. Antibody binding blocks phosphorylation and does not interfere with EGF binding.
Formulation PBS, pH 7.4
State: Purified
State: Liquid purified Ig fraction
Concentration 1 mg/ml
Purification Protein G Chromatography
Gene Name Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1
Background Epidermal growth factor receptor (EGFR) is a tyrosine protein kinase comprised of two different components of different molecular weights. Both components contain phosphotyrosine and phosphothreonine but only the higher molecular weight component contains phosphoserine. EGFR signaling involves small GTPases of the Rho family and EGFR trafficking involves small GTPases of the Rab family. EGFR expression is widespread in both normal and cancerous tissues.
Synonyms Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1
Reference Data
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton
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68 Mouse Clones