Aurora B (AURKB) (1-344) Sheep Polyclonal Antibody
Aurora B (AURKB) (1-344) sheep polyclonal antibody, Purified
|Recommended Dilution||Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Western Blot: 0.2 µg/ml.
|Immunogen||AURKB antibody was raised against recombinant Human His(6)-Aurora B [residues 1-344] expressed in insect cells.|
|Specificity||This antibody recognizes Aurora Kinase B (AURKB/ARK2) at aa 1-344.|
|Formulation||PBS containing 0.09% Sodium Azide as preservative
State: Liquid purified Ig fraction
|Storage||Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Gene Name||Homo sapiens aurora kinase B (AURKB), transcript variant 1|
|Background||ARK2, an Aurora/IPL1-like protein kinase, functions in bipolar chromosome orientation, kinetochore assembly, spindle checkpoint and microtubule dynamics, and chromosome condensation and cohesion. ARK2 has been shown to be physically associated with inner centromere protein (INCENP) during mitosis, and activated ARK2 has been shown to phosphorylate histone H3. The Ark2 gene has been mapped to 17p13.1, a region that is frequently deleted in tumors, and has been shown to be transcriptionally overexpressed in many tumor cell lines. Overexpression of ARK2 disrupts cleavage furrow formation without affecting nuclear division, often resulting in multinuclearity and polyploidy.|
|Synonyms||Aurora-B, Aurora/IPL1-related kinase 2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12|
|Protein Families||Druggable Genome, Protein Kinase, Stem cell - Pluripotency|
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