Netrin 1 (NTN1) Rabbit Polyclonal Antibody

CAT#: AP20679PU-N

Netrin 1 (NTN1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Netrin-1 antibody (Cat.-No AP20679PU-N) in extracts from COS7 cells.

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  Immunohistochemistry analysis of Netrin-1 antibody (Cat.-No AP20679PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Netrin-1 protein.
  (region surrounding Gln533)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% (by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~68 kDa
• Gene Name: netrin 1
• Database Link:
  Entrez Gene 18208 MouseEntrez Gene 114523 RatEntrez Gene 9423 Human
  UniProt ID O95631
• Background: Netrin-G1 ligand (NGL1) is a transmembrane protein containing leucine-rich repeat (LRR) and immunoglobulin (Ig) domains that specifically interact with netrin-G1 through its LRR region. Whereas netrin-G1 is expressed highly in mouse thalamic axons, NGL1 is most abundant in the striatum and the cerebral cortex. NGL1 is implicated in facilitating axonal growth of the vertebrate CNS. Membrane-bound netrin-G1 acts as an axonal receptor, whereas the LRR-containing transmembrane protein NGL1 acts as a ligand in promoting the growth of thalamic axons.
• Synonyms: NTN1, NTN1L

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Axon guidance