BMP2 (aa 261-290) Rabbit Polyclonal Antibody
BMP2 (aa 261-290) rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Western blot: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide, corresponding to amino acids 261-290 of Human BMP2.|
|Specificity||This antibody detects endogenous levels of BMP-2 protein.
(region surrounding Pro275)
|Formulation||Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Preservative: 0.05% Sodium Azide
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Predicted Protein Size||~ 44 kDa|
|Gene Name||Homo sapiens bone morphogenetic protein 2 (BMP2)|
|Background||Bone morphogenic proteins (BMPs) are members of the TGFbeta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFβ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.|
|Synonyms||Bone morphogenetic protein 2, BMP-2, BMP-2A|
|Protein Families||Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane|
|Protein Pathways||Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway|