BMP6 Rabbit Polyclonal Antibody

CAT#: AP20577PU-N

BMP6 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of BMP-6 antibody in extracts from 293 cells treated with TNF.

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  Western blot (WB) analysis of BMP-6 antibody at 1/500 dilution. Lane 1: Jurkat cell lysate. Lane 2: Raw264.7 cell lysate. Lane 3: PC12 whole cell lysate.

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  Immunohistochemistry (IHC) analyzes of BMP-6 antibody in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 125-170 of Human BMP-6.
• Specificity: This antibody detects endogenous levels of BMP-6 protein.
  (region surrounding Ala152)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~42, 57 kDa
• Gene Name: bone morphogenetic protein 6
• Database Link:
  Entrez Gene 12161 MouseEntrez Gene 25644 RatEntrez Gene 654 Human
  UniProt ID P22004
• Background: Bone morphogenic proteins (BMPs) are members of the TGFbeta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFbeta receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
• Synonyms: BMP-6, VGR, VGR1, Bone morphogenetic protein 6

Reference Data

• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway
• Protein Pathways: Hedgehog signaling pathway, TGF-beta signaling pathway