NMDAR2B (GRIN2B) Rabbit Polyclonal Antibody
NMDAR2B (GRIN2B) rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Western blot: 1/500 - 1/1000.|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide, corresponding to the C-terminus of Human NMDAε2|
|Specificity||This antibody detects endogenous levels of NMDAR2B protein.
(region surrounding Ser1468)
|Formulation||Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% sodium azide
|Purification||Affinity chromatography (> 95% (by SDS-PAGE)|
|Storage||Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||~ 165 kDa|
|Gene Name||Homo sapiens glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B)|
|Background||NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA).Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease and also epilepsy and ischemic neuronal cell death.|
|Synonyms||GRIN2B, NMDA Receptor 2B|
|Protein Families||Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane|
|Protein Pathways||Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Huntington's disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Systemic lupus erythematosus|
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