Arrestin C (ARR3) Rabbit Polyclonal Antibody

CAT#: AP20474PU-N

Arrestin C (ARR3) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Arrestin-C antibody (Cat.-No.: AP20474PU-N) in extracts from LOVO cells.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human Arrestin-C.
• Specificity: This antibody detects endogenous levels of Arrestin-C protein.
  (region surrounding Glu374)
• Formulation: Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~40, 43 kDa
• Gene Name: arrestin 3 retinal (X-arrestin)
• Database Link:
  Entrez Gene 407 Human
  UniProt ID P36575
• Background: Members of Arrestin/beta-Arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters or sensory signals. Arrestin-C, also known as retinal cone Arrestin-3, X-Arrestin or cArr, is a member of the Arrestin family of proteins. It is predominantly found in the retina and pineal gland and localizes to the inner and outer segments of red-, green- and blue-cone photoreceptors and the inner plexiform regions. Two Arrestin-C isoforms exist due to alternative splicing. Isoform 1 is the mature full length protein and isoform 2 is truncated, ending with an arginine for amino acid residue 359. Arrestin-C expression is stimulated by retinoic acid. It may play a role in retina-specific signal transduction and bind to photoactivated-phosphorylated red/green opsins. In addition, Arrestin-C forms homodimers and oligomers with beta-Arrestins and may regulate beta-Arrestin mediated signaling.
• Synonyms: ARRX, CAR, Cone arrestin, Retinal cone arrestin-3, X-arrestin, C-ARR, C-Arrestin

Reference Data

• Protein Families: Druggable Genome