Flt3 ligand (FLT3LG) Rabbit Polyclonal Antibody
Flt3 ligand (FLT3LG) rabbit polyclonal antibody, Aff - Purified
Product Datasheet for 'AP20420PU-N'
|Recommend Dilution||Western blot: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide, corresponding to amino acids 180-230 of Human Flt3-L.|
|Specificity||This antibody detects endogenous levels of Flt3-L protein.
(region surrounding His206)
|Formulation||Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Preservative: 0.05% Sodium Azide
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Predicted Protein Size||~26 kDa|
|Gene Name||Homo sapiens fms related tyrosine kinase 3 ligand (FLT3LG), transcript variant 3|
|Background||Flt 3 ligand (Flt 3-L), variously designated Flt 3/Flk 2 ligand or FL, is a 17 kDa hematopoietic growth factor that stimulates the proliferation of stem and CD34+ progenitor cells and has been cloned from both mouse and human genomes. Flt 3-L is a potent in vitro growth stimulator of granulocytemacrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and G-CSF-dependent granulocyte-macrophage committed precursors from Lin CD34+ bone marrow cells as well as other primitive B cell populations. Additionally, Flt 3-L stimulates the proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Flt 3-L does not, however, affect the growth of erythroid-committed progenitors. A Flt-3 ligand exists in two forms and is active as both a soluble and as a membrane-bound ligand. The Flt 3-L receptor, Flt 3, is a tyrosine kinase expressed on CD34+ cells that shares a high degree of homology with the SCF (stem cell factor) receptor, c-Kit and c-Fms.|
|Synonyms||SL cytokine, FLT3LG, Flt3L|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane|
|Protein Pathways||Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer|
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