Flt3 ligand (FLT3LG) Rabbit Polyclonal Antibody
Rabbit polyclonal anti-Flt3 ligand antibody, Aff - Purified
Product Datasheet for 'AP20420PU-N'
|Recommend Dilution||IHC, WB|
|Formulation||Phosphate buffered saline (PBS), pH~7.2|
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Predicted Protein Size||~26.2 kDa|
|Gene Name||fms related tyrosine kinase 3 ligand|
|Background||Flt 3 ligand (Flt 3-L), variously designated Flt 3/Flk 2 ligand or FL, is a 17 kDa hematopoietic growth factor that stimulates the proliferation of stem and CD34+ progenitor cells and has been cloned from both mouse and human genomes. Flt 3-L is a potent in vitro growth stimulator of granulocytemacrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and G-CSF-dependent granulocyte-macrophage committed precursors from Lin CD34+ bone marrow cells as well as other primitive B cell populations. Additionally, Flt 3-L stimulates the proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Flt 3-L does not, however, affect the growth of erythroid-committed progenitors. A Flt-3 ligand exists in two forms and is active as both a soluble and as a membrane-bound ligand. The Flt 3-L receptor, Flt 3, is a tyrosine kinase expressed on CD34+ cells that shares a high degree of homology with the SCF (stem cell factor) receptor, c-Kit and c-Fms.|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane|
|Protein Pathways||Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer|
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