p75 NGF Receptor (NGFR) Rabbit Polyclonal Antibody

CAT#: AP20406PU-N

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p75 NGF Receptor (NGFR) rabbit polyclonal antibody, Aff - Purified

USD 370.00

2 Weeks

    • 100 ug

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Product Data
Applications IF, WB
Recommended Dilution Western blot: 1/500-1/1000.
Immunofluorescence: 1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of NGFR p75 protein.
(region surrounding Pro150)
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction > 95% (by SDS-PAGE)
Preservative: 15 mM sodium azide
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 45,75 kDa
Gene Name Homo sapiens nerve growth factor receptor (NGFR)
Background Nerve Growth Factor Receptor, also termed NGFR p75, p75NTR, or CD271 is the low affinity NGFR (LNGFR) which binds NGF and other neurotrophins including BDNF, NT3, NT4/5 with similar, low affinity. NGFR p75 is a 75kD transmembrane glycoprotein (399 a.a.) consisting of an extracellular domain (222 a.a.) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 a.a.), and a cytoplasmic domain (155 a.a.). NGFR p75 is mainly expressed in Schwann cells and neurons and in a variety of non neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. The signal transduction mechanisms and components leading to NGFR p75 multiple signals are complex and not well understood.
Synonyms TNFRSF16
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Neurotrophin signaling pathway
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