PDGF Receptor beta (PDGFRB) Rabbit Polyclonal Antibody

CAT#: AP20313PU-N

PDGF Receptor beta (PDGFRB) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry analyzes of PDGFR-β antibody (Cat.-No.: AP20313PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC
• Recommended Dilution: Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of PDGFR-beta protein.
• Formulation: Phosphate buffered saline (PBS), pH~7.2 with 0.05% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 124, 190 kDa
• Gene Name: platelet derived growth factor receptor beta
• Database Link:
  Entrez Gene 18596 MouseEntrez Gene 24629 RatEntrez Gene 5159 Human
  UniProt ID P09619
• Background: Platelet-derived growth factor receptors exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-bet,a have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.
• Synonyms: PDGF-R-beta, PDGF Receptor beta

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
• Protein Pathways: Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton