TMPRSS2 (N-term) Rabbit Polyclonal Antibody

CAT#: AP17793PU-N

TMPRSS2 (N-term) rabbit polyclonal antibody

Product Images

Western blot analysis of TMPRSS2 antibody (N-term) in NCI-H460 cell line lysates (35ug/lane). TMPRSS2 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of human TMPRSS2
• Specificity: This antibody reacts to TMPRSS2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: transmembrane protease, serine 2
• Database Link:
  Entrez Gene 7113 Human
  UniProt ID O15393
• Background: TMPRSS2 is a protein that belongs to the serine protease family. The protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. Its gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.
• Synonyms: Transmembrane protease serine 2, PRSS10, Serine protease 10

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane