Thymine DNA glycosylase (TDG) (C-term) Rabbit Polyclonal Antibody

CAT#: AP17780PU-N

Thymine DNA glycosylase (TDG) (C-term) rabbit polyclonal antibody

Product Images

Western blot analysis of TDG antibody (C-term) in K562 cell line lysates (35ug/lane). TDG (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human TDG
• Specificity: This antibody reacts to TDG.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: thymine DNA glycosylase
• Database Link:
  Entrez Gene 6996 Human
  UniProt ID Q13569
• Background: The protein TDG belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.
• Synonyms: E130317C12Rik; hTDG; JZA-3; Jza1; OTTMUSP00000028912; OTTMUSP00000028913

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair