KMT5C (Center) Rabbit Polyclonal Antibody

CAT#: AP17772PU-N

KMT5C (Center) rabbit polyclonal antibody

Product Images

Western blot analysis of SUV4-20H2 antibody (Center) in mouse stomach tissue lysates (35ug/lane). SUV4-20H2 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human SUV420H2
• Specificity: This antibody reacts to SUV4-20H2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: lysine methyltransferase 5C
• Database Link:
  Entrez Gene 84787 Human
  UniProt ID Q86Y97
• Background: SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).
• Synonyms: Lysine N-methyltransferase 5C

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation