COMP (Center) Rabbit Polyclonal Antibody

CAT#: AP17228PU-N

COMP (Center) rabbit polyclonal antibody

Product Images

Western blot analysis of COMP Antibody (Center) in Jurkat cell line lysates (35 ug/lane). COMP (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:100 - 1:500.
  ELISA: 1:1,000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human COMP
• Specificity: This antibody detects COMP at Center.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Purified through a protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cartilage oligomeric matrix protein
• Database Link:
  Entrez Gene 1311 Human
  UniProt ID P49747
• Background: COMP is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations.
• Synonyms: Cartilage oligomeric matrix protein
• Note: Molecular weight: 82860 Da

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: ECM-receptor interaction, Focal adhesion, TGF-beta signaling pathway