AKAP9 Goat Polyclonal Antibody
Goat polyclonal anti-AKAP9 (C-term) antibody, Aff - Purified
Product Datasheet for 'AP16328PU-N'
|Recommend Dilution||ELISA, IHC, WB|
|Immunogen||Peptide with sequence C-SGSTTQFHAGMR, from the C Terminus of the protein sequence|
|Formulation||Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Predicted Protein Size||~0.5 kDa|
|Gene Name||A-kinase anchoring protein 9|
|Background||AKAP9 is a novel cytoskeletal protein specifically concentrated in the neuromuscular junction and neuronal synapes that interacts with specific splice variants of NMDA Receptor Subunit NR1 in a C1 exon cassette dependent manner. It has also been shown to physically attach the type I protein phosphatase (PP1) and the adenosine 3',5'-mono-phosphate (cAMP) dependent protein kinase (PKA) holoenzyme to NMDA receptors to regulate channel activity. NMDA receptors are involved with many important functions and dysfunctions of the nervous system, including synapse formation, synaptic plasticity, and excitotoxicity. AKAP9 research may lead to a clearer understanding of these neural processes by explaining how NMDA receptors are targeted to particular synapses, how this localization is regulated during development and synaptic activity, and how NMDA receptor activity is transduced into intracellular signals responsible for particular neuronal responses.|
|Synonyms||AKAP-9; AKAP350; AKAP450; CG-NAP; HYPERION; LQT11; MU-RMS-40.16A; PPP1R45; PRKA9; YOTIAO|
|Protein Families||Druggable Genome|
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