CGK2 (PRKG2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP14907PU-N

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CGK2 (PRKG2) (C-term) rabbit polyclonal antibody, Purified

 Product Datasheet for 'AP14907PU-N'

USD 415.00

2 Weeks

    • 400 ul

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Product Data
Applications IHC, WB
Recommend Dilution ELISA: 1/1,000.
Immunohistochemistry: 1/50 - 1/100.
Western Blot: 1/100 - 1/500.
Reactivity Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human cGKII.
Specificity This antiobdy reacts to cGKII.
Formulation PBS with 0.09% (W/V) sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Gene Name protein kinase, cGMP-dependent, type II
Background cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50% of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.
Synonyms PRKG2, PRKGR2, cGKII
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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BOGO Free lysates
68 Mouse Clones