CGK2 (PRKG2) (C-term) Rabbit Polyclonal Antibody
CGK2 (PRKG2) (C-term) rabbit polyclonal antibody, Purified
Product Datasheet for 'AP14907PU-N'
|Recommend Dilution||ELISA: 1/1,000.
Immunohistochemistry: 1/50 - 1/100.
Western Blot: 1/100 - 1/500.
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human cGKII.|
|Specificity||This antiobdy reacts to cGKII.|
|Formulation||PBS with 0.09% (W/V) sodium azide
State: Liquid purified Ig
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Gene Name||protein kinase, cGMP-dependent, type II|
|Background||cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50% of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.|
|Synonyms||PRKG2, PRKGR2, cGKII|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.