Zinc finger MIZ domain containing protein 1 (ZMIZ1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP13210PU-N

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Zinc finger MIZ domain containing protein 1 (ZMIZ1) (C-term) rabbit polyclonal antibody, Purified


Product Datasheet for 'AP13210PU-N'


USD 450.00


Availability*
2 Weeks

Size
    • 400 ul


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Specifications

Product Data
Applications IHC, WB
Recommend Dilution

ELISA: 1/1,000.
Western Blot: 1/50-1/100.
Immunohistochemistry on Paraffin Sections: 1/50-1/100.

Reactivity Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 596~626 amino acids from the C-terminal region of Human RAI17
Specificity This antibody reacts to RAI17.
Formulation PBS with 0.09% (W/V) Sodium Azide as preservative
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Gene Name zinc finger MIZ-type containing 1
Background Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
Synonyms KIAA1224, ZIMP10
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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