Gastrin (GAST) Rabbit Polyclonal Antibody

CAT#: AP09558SU-N

Gastrin (GAST) rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: IF, IHC
• Recommended Dilution: Immunocytochemistry.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Embedded Sections: No proteolytic treatment required.
  Recommended Dilutions: 1/50-1/100.
  Incubation Time: 1 h at room temperature or overnight at 2-8°C.
• Reactivities: Human, Mammalian
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Human gastrin 17 conjugated to BSA
• Specificity: Gastrin-secreting cells are numerous in the antrum and a few are found in the proximal duodenum. The antibody can be used for the diagnosis of gastrin-producing tumors which are mainly found in the pancreas and occasionally in the stomach and the duodenum.
• Formulation: PBS
  State: Serum
  State: Liquid Serum
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: gastrin
• Database Link:
  Entrez Gene 2520 Human
  UniProt ID P01350
• Background: Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin.
• Synonyms: GAST, GAS

Reference Data

• Protein Families: Druggable Genome, Secreted Protein