CIITA Rabbit Polyclonal Antibody
CIITA rabbit polyclonal antibody, Serum
Product Datasheet for 'AP09075SU-N'
|Immunogen||Peptide corresponding to a region near the N-terminal end of the human CIITA gene conjugated to Keyhole Limpet Hemocyanin (KLH)|
|Specificity||This antibody detetcs CIITA.|
|Formulation||0.01% (w/v) Sodium Azide, containing no stabilizer.
State: Liquid sterile filtered antibody, prepared from monospecific antiserum by delipidation and defibrination
|Concentration||90.0 mg/ml (by Refractometry)|
|Gene Name||class II, major histocompatibility complex, transactivator|
|Background||The transactivator CIITA regulates basal and interferon-induced expression of MHC class II genes. CIITA restores expression of all MHC II gene expression in mutant cells and corrects regulatory defects of those genes. Activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. CIITA may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.|
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