CARD15 (NOD2) (C-term) Rabbit Polyclonal Antibody

SKU AP08944PU-N

CARD15 (NOD2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.; Immunocytochemistry: 10 µg/ml.; Immunohistochemistry on Paraffin Sections: 3 µg/ml.; Western Blot: 2 - 4 µg/ml.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to 14 amino acids at the carboxy terminus of Human NOD2
• Specificity: This antibody recognizes NOD2 Protein (CARD15) at C-Terminus.
• Buffer: PBS containing 0.02% Sodium Azide as preservative; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: nucleotide binding oligomerization domain containing 2
• Database Link:
  Q9HC29
• Background: CARD15 (Nod2) is a member of the Nod1/Apaf-1 family of intracellular proteins that contain an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and a C-terminal regulatory domain. CARD15 induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It also confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Unlike Nod1, this homologue is primary expressed in monocytes. Defects in CARD15 are associated with Blau Syndrome (BS) and Crohn's Disease (CD), and are a cause of susceptibility to ulcerative colitis.
• Synonyms: IBD1

Reference Data