BAFF (TNFSF13B) (C-term) Rabbit Polyclonal Antibody

CAT#: AP08477PU-N

BAFF (TNFSF13B) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

CD257/BAFF antibody staining of Formalin-Fixed Paraffin-Embedded Human Tonsil at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 0.5 - 2 µg/ml.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids 254-269 (C-terminal) of Human BAFF.
• Specificity: This antibody recognizes CD257/BAFF.
• Formulation: 0.2 ml PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Protein G Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 10673 Human
  UniProt ID Q9Y275
• Background: Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1, THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase, BAFF (for B cell activating factor belonging to the TNF family) and Blys (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS/BAFF/THANK acts as a potent B cell growth factor. This protein is expressed abundantly in peripheral blood lymphocytes, specifically in monocytes and macrophages. Its regulation is upregulated by interferon gamma. Overexpression of BLyS/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc. Two receptors for BLyS/BAFF have been identified and termed as BCMA and TACI.
• Synonyms: TNFSF13B, BLYS, TALL1, TNFSF20, ZTNF4