Activin Receptor Type IA (ACVR1) Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-ACVR1 Antibody, Aff - Purified
Product Datasheet for 'AP08420PU-N'
|Recommend Dilution||IHC, WB|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide within amino acids 475-509 of human ACVR1.|
|Formulation||PBS containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide as preservative.|
|Purification||Protein G Chromatography.|
|Predicted Protein Size||90.8 kDa|
|Gene Name||activin A receptor type 1|
|Background||Activin Receptor Type IA on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Activin receptor IA is highly conserved and is a receptor for BMP2 and BMP4.|
|Synonyms||ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane|
|Protein Pathways||Cytokine-cytokine receptor interaction, TGF-beta signaling pathway|
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