BACE2 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-BACE2 Antibody, Purified
Product Datasheet for 'AP07871PU-N'
|Recommend Dilution||IHC, WB|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic Peptide corresponding to Amino acids 44 to 59 of human BACE2 - KLH conjugated|
|Formulation||PBS containing 0.02% Sodium Azide as preservative|
|Purification||Liquid purified IgG fraction
|Predicted Protein Size||49.8KDa|
|Gene Name||beta-site APP-cleaving enzyme 2|
|Background||BACE2 (Memapsin 1) is a membrane-bound aspartic protease that is highly homologous with BACE1 (Memapsin 2). While BACE1 processes the amyloid precursor protein (APP) at a key step in generating the beta-amyloid peptide and presumably causes Alzheimer's disease (AD), BACE2 has not been demonstrated to be directly involved in APP processing, and its physiological functions remain to be determined. In vivo, BACE2 is expressed as a precursor protein containing pre-, pro-, protease, transmembrane, and cytosolic domains/peptides.|
|Protein Families||Transmembrane, Protease, Druggable Genome|
|Protein Pathways||Alzheimer's disease|
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