Cbl c (CBLC) Rabbit Polyclonal Antibody
Cbl c (CBLC) rabbit polyclonal antibody, Aff - Purified
|Applications||ELISA, IF, IHC, IP, WB|
|Recommended Dilution||ELISA: 1/10000 - 1/50000.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1/500 - 1/3000.
|Immunogen||Synthetic peptide - KLH conjugated corresponding to amino acids 444-458 of Human Cbl-c.|
|Specificity||This antibody recognizes RNF57/CBLC.|
|Formulation||0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide.
State: Aff - Purified
State: Liquid purified Ig fraction.
|Background||Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.|
|Synonyms||CBL3, CBL-C, CBL-3, RING finger protein 57|