hnRNP L (HNRNPL) Rabbit Polyclonal Antibody

CAT#: AP06669PU-N

hnRNP L (HNRNPL) rabbit polyclonal antibody, Aff - Purified


USD 465.00

3 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Immunofluorescence: 1/50-1/200.
Reactivities Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 30-80 of Human hnRNP L.
Specificity This antibody detects endogenous levels of hnRNP L protein.
(region surrounding Gly58)
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% sodium azide
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 60 kDa
Gene Name heterogeneous nuclear ribonucleoprotein L
Background Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription, pre-mRNA processing and mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II). There are approximately 20 known hnRNP proteins, which range in size from 34 kDa to 120 kDa, and their complexes are the majorconstituents of the spliceosome. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB) and its homolog hnRNP L bind to the 3' end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of several viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a 57 kDa protein that is localized in the nucleoplasm. hnRNP L has a molecular mass of 68 kDa and like hnRNP I, is also localized in the nucleoplasm.
Synonyms HNRPL, P/OKcl.14, Heterogeneous nuclear ribonucleoprotein L
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.