Thrombin Receptor (F2R) Rabbit Polyclonal Antibody

CAT#: AP06630PU-N

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Thrombin Receptor (F2R) rabbit polyclonal antibody, Aff - Purified

Product Datasheet for 'AP06630PU-N'

USD 370.00

2 Weeks

    • 100 ug

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Product Data
Applications WB
Recommended Dilution Western blot: 1/500-1/1000.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to the N-terminal of Human Thrombin R.
Specificity This antibody detects endogenous levels of PAR1 protein.
(region surrounding Gly17)
Formulation Phosphate buffered saline (PBS), pH 7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Preservative: 0.05% Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 48 kDa
Gene Name coagulation factor II thrombin receptor
Background Thrombin receptor (also designated protease-activated receptor-1 or PAR-1), PAR-2 and PAR-3 compose a distinct class of G protein-coupled receptors activated by proteolysis. Cleavage of these receptors by proteases occurs within the amino-terminal extracellular domain. Thrombin, a serine protease involved in platelet aggregation and blood coagulation, activates the thrombin receptor, resulting in elevated intracellular calcium levels in platelets. Thrombin also cleaves PAR-3 in vitro, suggesting that PAR-3 may be involved in thrombosis or mitogenesis. Thrombin receptor and PAR-4 appear to account for most thrombin signaling in platelets. Activation of PAR-2 in vitro is induced by trypsin, suggesting that PAR-2 is not an alternative thrombin receptor. Cytokines including TNF-alpha and IL-1beta increase PAR-2 expression, indicating PAR-2 involvement in the acute inflammatory response.
Synonyms Proteinase-activated receptor 1, PAR-1, PAR1, CF2R
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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