Ku70 (XRCC6) Rabbit Polyclonal Antibody

CAT#: AP06485PU-N

Ku70 (XRCC6) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of XRCC6 antibody in extracts from hela cells.

• 

  Immunohistochemistry (IHC) analyzes of XRCC6 antibody in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 560-600 of Human Ku-70.
• Specificity: This antibody detects endogenous levels of XRCC6 protein.
  (region surrounding Arg586)
• Formulation: PBS, pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
  Preservative: 15 mM Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 70 kDa
• Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 6
• Database Link:
  Entrez Gene 2547 Human
  UniProt ID P12956
• Background: The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 (or p86), which is also known by the synonym Ku-80 (or p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation.
• Synonyms: G22P1, TLAA, CTCBF, CTC75