Ki67 (MKI67) Rabbit Polyclonal Antibody
Ki67 (MKI67) rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Immunofluoresecnce: 1/50-1/200.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.
|Immunogen||Synthetic peptide, corresponding to amino acids C-terminus of Human Ki-67.|
|Specificity||This antibody detects endogenous levels of Ki67 protein.
(region surrounding Val3242)
|Formulation||Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE)
Preservative: 0.05% Sodium Azide
|Purification||Affinity Chromatography using epitope-specific immunogen|
Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||~ 359 kDa|
|Background||Ki-67 is a nuclear protein that is expressed in proliferating cells and may be required for maintaining cell proliferation. Ki-67 has been used as a marker for cell proliferation of solid tumors and some hematological malignancies. A correlation has been demonstrated between Ki-67 index and the histopathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors.|
|Synonyms||Ki67 antigen, MKI67, Proliferation marker|