GABA A Receptor beta 1 (GABRB1) Rabbit Polyclonal Antibody
GABA A Receptor beta 1 (GABRB1) rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide, corresponding to amino acids 320-370 of Human GABAA Rβ1.|
|Specificity||This antibody detects endogenous levels of GABA-RB protein.
(region surrounding Arg328)
|Formulation||Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Preservative: 0.05% Sodium azide
|Purification||Affinity Chromatography using epitope-specific immunogen.|
Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||~ 54 kDa|
|Background||GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (γ-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA Rβ1-3, GABAA Rε, GABAA Rδ, GABAA Rγ1-3, GABAA Rγ1 and GABAA Rγ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.|
|Synonyms||GABRB-1, GABA A receptor subunit beta-1|