GABA A Receptor beta 1 (GABRB1) Rabbit Polyclonal Antibody

CAT#: AP06129PU-N

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GABA A Receptor beta 1 (GABRB1) rabbit polyclonal antibody, Aff - Purified


Product Datasheet for 'AP06129PU-N'


USD 370.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IHC, WB
Recommended Dilution Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections:
1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 320-370 of Human GABAA Rβ1.
Specificity This antibody detects endogenous levels of GABA-RB protein.
(region surrounding Arg328)
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Preservative: 0.05% Sodium azide
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Predicted Protein Size ~ 54 kDa
Background GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (γ-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA Rβ1-3, GABAA Rε, GABAA Rδ, GABAA Rγ1-3, GABAA Rγ1 and GABAA Rγ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.
Synonyms GABRB-1, GABA A receptor subunit beta-1
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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