FGFR3 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-FGFR3 Antibody, Aff - Purified
Product Datasheet for 'AP06120PU-N'
|Recommend Dilution||IHC, WB|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide, corresponding to amino acids 120-167 of Human FGFR3.|
|Formulation||Phosphate buffered saline (PBS), pH~7.2|
|Purification||Affinity Chromatography using epitope-specific immunogen.|
|Predicted Protein Size||85.7 kDa|
|Gene Name||fibroblast growth factor receptor 3|
|Background||Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors.These include the Flg receptor or FGFR-1, the Bek receptor (or FGFR-2), FGFR-3, FGFR- 4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligandbinding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Bek (also designated K-sam) maps to chromosome 10q26 and is alternatively spliced to produce several isoforms. Heterogeneous mutations in Bek are associated with a range of craniosynostosis syndromes including Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome and Apert syndrome.|
|Synonyms||ACH; CD333; CEK2; HSFGFR3EX; JTK4|
|Protein Families||Druggable Genome, Protein Kinase, Transmembrane|
|Protein Pathways||Bladder cancer, Endocytosis, MAPK signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.