SLUG (SNAI2) Rabbit Polyclonal Antibody

CAT#: AP05600PU-N

SLUG (SNAI2) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of whole cell lysate from HEK293 human epithelial kidney cells probed with Rabbit anti Human Slug at 0.5 (A), and 1 (B) and 2 (C) ug/ml

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  Immunofluorescence staining of human kidney with Rabbit anti Human Slug

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 0.5-2.0 µg/ml. Detects a band of approximately 30kDa in 293 cell lysate.
  Immunocytochemistry/Immunofluorescence.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: 13 amino acid peptide sequence near the centre of Human Slug
• Specificity: This antibody detects Slug, a member of the Snail family of zinc finger transcription factors, whose expression is induced by FGF, BMP, and TGF-beta. This antibody is not cross-reactive with Snail.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: snail family transcriptional repressor 2
• Database Link:
  Entrez Gene 20583 MouseEntrez Gene 6591 Human
  UniProt ID O43623
• Background: Slug is a 29kD transcriptional repressor, which functions by binding to E-box motifs and inhibiting gene expression by recruiting histone deacetylase-1 (HDAC-1).
  Slug controls the expression of a wide variety of genes including TP53, BRCA2, PUM and CDH1, and has important roles in apoptosis and epithelial-mesenchymal transition. It is also thought to function in neural crest development. Slug expression in breast, oesophageal, and colorectal carcinomas has been correlated with poor prognosis for survival.
• Synonyms: SLUGH

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Adherens junction