FBXW7 Rabbit Polyclonal Antibody

CAT#: AP05288PU-N

FBXW7 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis using FBXW7 antibody on human brain lysate. Antibody used at 1 ug/ml dilution and is used alone (1) or incubated with blocking peptide (2). Visualized using mouse anti-rabbit HRP at 1:200K dilution.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1:400 starting dilution.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide dervied from the human FBXW7 protein
• Specificity: This antibody detects FBXW7, widely expressed.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinty chromatograpghy
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: F-box and WD repeat domain containing 7
• Database Link:
  Entrez Gene 55294 Human
  UniProt ID Q969H0
• Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
• Synonyms: FBW7, FBX30, SEL10, Archipelago homolog, hAgo, SEL-10, hCDC4