CACNA1E Rabbit Polyclonal Antibody

CAT#: AP05133PU-N

CACNA1E rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 5-10 µg/ml.
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the Rat alpha1E Calcium Channel conjugated to KLH.
• Specificity: This antibody recognizes Alpha 1E Calcium Channel CACNA1E.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.08% Sodium Azide
• Concentration: lot specific
• Purification: Ammonium sulfate precipitation
• Conjugation: Unconjugated
• Storage: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: calcium voltage-gated channel subunit alpha1 E
• Database Link:
  Entrez Gene 777 Human
  UniProt ID Q15878
• Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by nickel, and partially by omega-agatoxin-iiia (omega-aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-ctx-GVIA), and omega-agatoxin-IVA (omega-aga-IVA). Calcium channels contaning alpha-1e subunit could be involved in the modulation of firing patterns of neurons.
• Synonyms: CACH6, CACNL1A6, Cav2.3, Brain calcium channel II