GSK3 beta (GSK3B) Rabbit Polyclonal Antibody

CAT#: AP02786PU-S

GSK3 beta (GSK3B) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extract from 293 cells, untreated or treated with insulin (40µM, 30min), using GSK3β Antibody (Lane 1 and 2) and GSK3β (PTyr216) Antibody (Lane 3 and 4).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1:500~1:1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human GSK3β around the phosphorylation site of tyrosine 216 (V-S-YP-I-C).
• Specificity: GSK3β antibody detects endogenous levels of total GSK3β.
• Formulation: PBS (without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  State: Aff - Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: glycogen synthase kinase 3 beta
• Database Link:
  Entrez Gene 2932 Human
  UniProt ID P49841
• Background: Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation.
• Synonyms: GSK-3 beta, Glycogen synthase kinase-3 beta, GSK3B