JAK1 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-JAK1 Antibody, Aff - Purified
Product Datasheet for 'AP02433PU-S'
|Recommend Dilution||IHC, WB|
|Reactivity||Human, Mouse, Rat|
|Immunogen||The antiserum was produced against synthesized phosphopeptide derived from Human JAK1 around the phosphorylation site of tyrosine 1022 (K-E-YP-Y-T).|
|Formulation||PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol|
|Predicted Protein Size||133.1 kDa|
|Gene Name||Janus kinase 1|
|Background||Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]|
|Synonyms||JAK1A; JAK1B; JTK3|
|Protein Families||Druggable Genome, Protein Kinase|
|Protein Pathways||Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer|
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