JAK1 Rabbit Polyclonal Antibody

CAT#: AP02433PU-S

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Rabbit Polyclonal Anti-JAK1 Antibody, Aff - Purified


 Product Datasheet for 'AP02433PU-S'

USD 230.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Applications IHC, WB
Recommend Dilution IHC, WB
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The antiserum was produced against synthesized phosphopeptide derived from Human JAK1 around the phosphorylation site of tyrosine 1022 (K-E-YP-Y-T).
Formulation PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol
Concentration 1 mg/ml
Purification affinity Chromatography
Predicted Protein Size 133.1 kDa
Gene Name Janus kinase 1
Background Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
Synonyms JAK1A; JAK1B; JTK3
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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ANTIBODY VALIDATION 101
BOGO Free lysates
68 Mouse Clones