Neutrophil Elastase (ELANE) Goat Polyclonal Antibody

CAT#: AP02164SU-N

Neutrophil Elastase (ELANE) goat polyclonal antibody, Serum

Specifications

Product Data

• Applications: ELISA, R, WB
• Recommended Dilution: ELISA (1/8.000).
  RIA (1/10.000).
  Western blot (1/500).
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Human purified PMN Elastase
• Specificity: This antibody detects Human PMN Elastase.
  Other species not tested.
• Formulation: State: Serum
  State: Lyophilized serum
• Reconstitution Method: Restore in aqua bidest to initial volume.
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: elastase, neutrophil expressed
• Database Link:
  Entrez Gene 1991 Human
  UniProt ID P08246
• Background: Elastases form a subfamily of serine proteases that hydrolyse many proteins in addition to elastin. Neutrophil elastase (elastase 2) hydrolyses proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia.
• Synonyms: ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE