Androgen Receptor (AR) pSer650 Rabbit Polyclonal Antibody

CAT#: AP01525PU-N

Androgen Receptor (AR) pSer650 rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry (IHC) analysis of p-Androgen Receptor (pSer650) antibody (Cat.-No.: AP01525PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: p-Androgen Receptor (pSer650) antibody detects endogenous levels of p-Androgen Receptor protein.
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: androgen receptor
• Database Link:
  Entrez Gene 367 Human
  UniProt ID P10275
• Background: Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of liganddependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT). The rates of association and dissociation of T are about three times more rapid than those of DHT. This difference in binding kinetic may account for the different physiological effects of T and DHT. Androgen binding results in an at least six-fold increase in androgen receptor stability. Akt phosphorylates human AR at Serines 210 and 790. The synthetic androgen R1881 elevates phosphorylation of Serines 308 and 650 in vitro.
• Synonyms: Dihydrotestosterone receptor, DHTR, NR3C4