GABA B Receptor 1 (GABBR1) Rabbit Polyclonal Antibody

CAT#: AP01268PU-N

GABA B Receptor 1 (GABBR1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis with extracts from K562 cells using GABBR1 antibody.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 930-950 of Human GABAB R1.
• Specificity: This antibody detects endogenous levels of GABBR1 protein (region surrounding Pro931).
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% Sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 110 kDa
• Gene Name: gamma-aminobutyric acid type B receptor subunit 1
• Database Link:
  Entrez Gene 54393 MouseEntrez Gene 81657 RatEntrez Gene 2550 Human
  UniProt ID Q9UBS5
• Background: GAD-65 and GAD-67, glutamate decarboxylases of 65 kDa and 67 kDa, respectively, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA (gamma-aminobutyric acid) functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA Rβ1-3, GABAA Rε , GABAA Rδ, GABAA Rγ1-3, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
• Synonyms: GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1, GPRC3A

Reference Data

• Protein Families: Druggable Genome, GPCR, Secreted Protein, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction