Cannabinoid Receptor I (CNR1) Rabbit Polyclonal Antibody

CAT#: AP01265PU-N

Cannabinoid Receptor I (CNR1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CB1 antibody at 1/500 dilution Lane 1: A549 cell lysate. Lane 2: Mouse lung tissue lysate. Lane 3: Rat lung tissue lysate.

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  Immunohistochemical analysis with paraffin-embedded Human colorectal carcinoma tissue using Cannabinoid receptor 1 antibody

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  Immunohistochemical analysis with paraffin-embedded mouse brain tissue using Cannabinoid receptor 1 antibody.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids 150-200 of Human CB1.
• Specificity: This antibody detects endogenous levels of Cannabinoid receptor 1 (region surrounding Phe189).
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (>95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 53 kDa
• Gene Name: cannabinoid receptor 1 (brain)
• Database Link:
  Entrez Gene 1268 Human
  UniProt ID P21554
• Background: The cannabinoid receptors (CB1 and CB2) are G protein-coupled receptors that inhibit adenylate cyclase activity in response to psychoactive cannabinoids. CB1 is expressed in brain tissue and, in low levels, in testis. CB2 is expressed only by cells of the immune system. The cannabinoid receptors mediate most of the cannabinoid-induced responses in a dose-dependent, stereoselective manner. This response system is thought to be involved in specific brain functions, such as nociception, control of movement, memory and neuroendocrine regulation, as well as having a possible role in brain development. In addition, CB1 may mediate the addictive behavior involved with the use of psychoactive cannabinoids, such as THC in marijuana.
• Synonyms: CB1, CB-R, CNR1, CNR, CANN6