Adenosine Receptor A2a (ADORA2A) Rabbit Polyclonal Antibody
Adenosine Receptor A2a (ADORA2A) rabbit polyclonal antibody, Aff - Purified
Product Datasheet for 'AP01259PU-N'
|Applications||ELISA, IF, IHC, WB|
|Recommend Dilution||Western Blot: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.
|Immunogen||Synthetic peptide, corresponding to amino acids 330-380 of Human ADORA2A.|
|Specificity||This antibody detects endogenous levels of Adenosine A2A-R protein. (region surrounding Tyr361)|
|Formulation||Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Preservative: 0.05% Sodium Azide
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Predicted Protein Size||~45 kDa|
|Background||Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response and the inhibition of protein synthesis. The adenosine receptors, including Adenosine A1-R, Adenosine A2A-R, Adenosine A2B-R and Adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthasis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNFα and blocks the endotoxin CD14 receptor signal transduction pathway.|
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