PMS2 Rabbit Polyclonal Antibody
PMS2 rabbit polyclonal antibody, Aff - Purified
Product Datasheet for 'AP00189PU-N'
|Applications||IHC, IP, WB|
|Recommend Dilution||Western Blot: 0.5-4 μg/ml.
Immunoprecipitation: 10-20 μg/ml.
Immunohistochemistry: 10-20 μg/ml.
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide surrounding amino acid 846 of human PMS2|
|Specificity||The antibody recognizes ~100 kDa PMS2.|
|Formulation||PBS containing 30% Glycerol, 0.5% BSA, and 0.01 % Thimerosal.
State: Aff - Purified
State: Liquid purified Ig fraction.
|Purification||Peptide Affinity Chromatography.|
|Background||Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 - 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.