PMS2 Rabbit Polyclonal Antibody

CAT#: AP00189PU-N

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PMS2 rabbit polyclonal antibody, Aff - Purified


 Product Datasheet for 'AP00189PU-N'

USD 355.00


Availability*
3 Days

Size
    • 100 ug


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Specifications

Product Data
Applications IHC, IP, WB
Recommend Dilution Western Blot: 0.5-4 μg/ml.
Immunoprecipitation: 10-20 μg/ml.
Immunohistochemistry: 10-20 μg/ml.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide surrounding amino acid 846 of human PMS2
Specificity The antibody recognizes ~100 kDa PMS2.
Formulation PBS containing 30% Glycerol, 0.5% BSA, and 0.01 % Thimerosal.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Purification Peptide Affinity Chromatography.
Background Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 - 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
Synonyms PMSL2
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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