Mfn2 (370-600, Cytopl. Dom.) Mouse Monoclonal Antibody [Clone ID: S153-5]

CAT#: AM60065PU-N

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Mfn2 (370-600, Cytopl. Dom.) mouse monoclonal antibody, clone S153-5, Purified


 Product Datasheet for 'AM60065PU-N'

USD 410.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Clone Name S153-5
Applications IF, IHC, WB
Recommend Dilution Western blot: 1/1000; 1 μg/ml was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot using HRP conjugated secondary antibody.
Immunocytochemistry.
Immunohistochemistry:Free floating sections, fixed in formaldehyde.
Reactivity Mouse, Rat
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Fusion protein amino acids 370-600 (Cytoplasmic, N-terminus) of mouse Mitofusin-2 (Accession no. Q80U63); ~55% identity with Mitofusin-1.
Specificity This antibody detects a 90 kDa protein. No cross-reactivity against Mitofusin-1.
Formulation PBS pH 7.4, 50% Glycerol, 0,09% Sodium azide
State: Purified
State: Liquid purified IgG fraction
Concentration 1.0 mg/ml
Purification Protein G chromatography
Background Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.
Synonyms MFN2, CPRP1, KIAA0214
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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