QK1 (QKI) (pan) Mouse Monoclonal Antibody [Clone ID: S147-6]

CAT#: AM60063PU-N

QK1 (QKI) (pan) mouse monoclonal antibody, clone S147-6, Purified


USD 530.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name S147-6
Applications IF, IHC, WB
Recommended Dilution Western blot: 1/1000; 1 μg/ml was sufficient for detection of QKI (pan) in 20 μg of rat brain lysate by colorimetric immunoblot analysis using HRP conjugated secondary antibody.
Immunocytochemistry.
Immunohistochemistry: Free floating sections, fixed in formaldehyde.
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Fusion protein amino acids 1-341 (full-length) of human QKI-5 (accession number Q96PU8, isoform 1) with >90% identity with QKI-6, QKI-7 and QKI-7b.
Specificity This antibody detects a 36-38 kDa protein corresponding to the molecular weight of QKI (pan).
Formulation PBS pH 7.4, 50% Glycerol, 0.09% Sodium azide
State: Purified
State: Liquid purified IgG fraction
Concentration lot specific
Purification Protein G chromatography
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Background QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients. Several isoforms are known.
Synonyms HKQ, QK1, QK3
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.