DHFR / DHFRP1 Mouse Monoclonal Antibody [Clone ID: AT5B2]

CAT#: AM50636PU-N

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DHFR / DHFRP1 mouse monoclonal antibody, clone AT5B2, Purified


Product Datasheet for 'AM50636PU-N'


USD 340.00


Availability*
2 Weeks

Size
    • 100 ul


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Specifications

Product Data
Clone Name AT5B2
Applications ELISA, WB
Recommended Dilution The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human DHFR (1-187aa) purified from E. coli.
Formulation Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
State: Purified
State: Liquid purified Ig fraction
Concentration 1.0 mg/ml
Purification Protein-A affinity chromatography
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens dihydrofolate reductase (DHFR), transcript variant 1
Background Dihydrofolate reductase (DHFR) catalyzes the DPH-dependent reduction of dihydrofolate to tetrahydrofolate, and is a crucial enzyme for the synthesis of purines, pyrimidines and some amino acids. Inhibition of the activity of this enzyme leads to arrest of D synthesis and cell death. Gene expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.
Synonyms Dihydrofolate reductase
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Folate biosynthesis, Metabolic pathways, One carbon pool by folate
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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