PLGF (PGF) Mouse Monoclonal Antibody [Clone ID: PLGF94]

CAT#: AM50307PU-T

PLGF (PGF) mouse monoclonal antibody, clone PLGF94, Purified

Specifications

Product Data

• Clone Name: PLGF94
• Recommended Dilution: ELISA: Use BSA free Antibody for coating.
  Functional Studies: Use Antibody without BSA & Azide.
  Positive Control: HepG2 cells or human placental and brain tumors.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human PLGF protein.
• Specificity: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Like VEGF, several PlGF vari- ants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PlGF signaling. While VEGF homodimers and VEGF/PlGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PlGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PlGF. VEGF and PlGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.
  Cellular Localization: Secreted (extracellular).
• Formulation: 10mM PBS
  State: Purified
  State: Liquid purified IgG fraction from Bioreactor Concentrate
  Stabilizer: 0.05% BSA
  Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Purification: Protein A/G Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 18 kDa
• Gene Name: placental growth factor
• Database Link:
  Entrez Gene 5228 Human
  UniProt ID P49763
• Synonyms: PGFL, PLGF, PlGF